Monte Carlo study of 3D image reconstruction of boron dose distribution in BNCT with CZT-based Compton camera.

Ramos D., Altieri S., Gong C., Iaselli G., Pugliese G., Protti N.
  Giovedì 15/09   15:00 - 18:30   Aula L - Christa Mc Auliffe   VI - Fisica applicata, acceleratori e beni culturali   Presentazione
The Boron Neutron Capture Therapy (BNCT) is a innovative radiotherapy with high selectivity capability over cancer tissue based on $^{10}B(n, \alpha)^{7}Li$ reaction. One of the main issues of BNCT effectiveness is to have a qualified $in vivo$ imaging dosimetry method. In this context it becomes important to be able to reconstruct the spatial distribution of the dose in the area of interest and the related isodose curves with imaging technique methods such as emission computed tomography. It has been proposed to reconstruct $in vivo$ imaging of the spatial distribution of the dose from $^{10}B$ by "Compton Camera techniques", taking advantage of the $478 {keV}$ photon emitted. In this contest is has been proposed a 3D cadmium-zinc-telluride (CZT) based drift strip detector, able to perform room temperature measurements of photon energy, timing and 3D positioning up to the MeV region. In this contribution we have performed Monte Carlo simulations and image reconstruction with iterative methods and morphological filtering to study the real-time imaging therapeutic dose monitoring capabilities of 3D CZT parallel planar field sensors using different gamma source configurations.