PHYSICOCHEMICAL characterization of F127 hydrogels.

Pini C., Brambilla E., Farronato G., Gallo S., Lenardi C., Orsini F., Tartaglia G.M., Locarno S.
  Mercoledì 14/09   13:30 - 18:30   Aula E - Rosalind Franklin   V - Biofisica e fisica medica   Presentazione
Thermogelling amphiphilic triblock copolymers based hydrogels have been found high interest in biomedical applications, as pharmaceutical drug delivery, since they can self-assemble into micelles in aqueous environment. Among different polymers of this family, Pluronic F127 based hydrogel presents a rapid gelation point at $37 {^{\circ}C}$, high permeability, fast dissolution, low toxicity, good drug release profile and compatibility with a great variety of chemical additives. Herein, we developed several F127 formulations with different additives able to modulate some physiochemical properties, such as reversible gelation, mucoadhesive gel formation below $30 {^{\circ}C}$, physiological $p$H, modulation of drug release, biocompatibility and biodegradability. Thanks to these features, F127 formulations are an ideal candidate for the development of products exploitable for different application such as periodontal therapy and cosmetic face masks. In addition, F127 hydrogels can be prepared in culture medium opening the chance of using such gel matrices for tissue engineering and cell encapsulation.